3 BIO - BIOINFO Genomic and Structural Bioinformatics

Subject list 1. Rational modification of the thermal resistance of proteins 2. Prediction of protein solubility changes upon mutation 3. Bioinformatic analysis of punctual variations in the human genome and of their relationship with disease 4. Rational design of vaccines: prediction of B-cell epitopes 5. Modeling the structure of membrane receptors and of their complex with ligands 6. Study of the dynamics of house dust mite allergens from family 5 7. Origin of the genetic code and prebiotic peptides 8. Dynamical modeling of gene expression in yeast and bacteria subject to perturbations 9. Design of synthetic gene circuits and noise control 10. Development of protein-protein docking algorithms 11. Development of an algorithm for side-chain positioning within proteins